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    Default GW-501516 The Original Fat-burning, Performance Enhancing SARM

    GW-501516 – original fat-burning, performance-enhancing SARM


    author: Mike Arnold

    Accelerated fat loss, increased muscle endurance, and improved metabolic health are just some of the ways that GW-5015156 can benefit our progress in bodybuilding. So it's not surprising that it became all the rage back when it was first released 5 or so years ago, but what was surprising was its relatively rapid fall from grace. Despite having a list of benefits applicable to almost every bodybuilding goal, his time in the spotlight was shortened when W. A. D. A (World anti-doping Agency) announced that GW-501516 was “withdrawn from research by a pharmaceutical company and discontinued when serious toxic substances were found in preclinical studies.”

    Presumably, GW-501516 was carcinogenic, causing tumors in experimental rats. Initial reports indicated that tumour formation occurred in many organs at all dosage levels, affecting the liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries, and uterus. This really took its toll on his resume, and soon warnings started popping up everywhere urging potential users to stay away. As you might expect, kneejerk's reaction was to stop using the material, which at the time seemed pretty reasonable. After all, if the W. A. D. A thought it was dangerous enough to issue an official statement warning athletes of its potential side effects, there was probably a good reason for it, or so it was assumed.

    When the research results were confirmed, GW's popularity plummeted—the General consensus was that it was too risky to use, but was this conclusion premature? At the time, the decision to hold off was probably a wise one, at least until we know a little more about this material. Additional information has since been released. A more accurate interpretation of the study results, as well as a meta-analysis of the available anecdotal data, helped to form a more favorable opinion of this S. A. R. M.

    When evaluating clinical trials, we should understand that while animal studies can serve as a useful guide in alerting us to potential problems in humans, we should not automatically assume that we will be affected in the same way. Extrapolation of this kind has never interested scientists, since the physiology of animals—in this case, rats—is often very different from that of humans.

    Clenbuterol, a widely used bodybuilding drug, is a great example. Animals are not only able to absorb huge doses (compared to humans) of maple without death, but also give it an extreme anabolic effect, increasing muscle mass by up to 30% in a short period of time. In addition, these animals did not train with weights, eat huge amounts of protein, or engage in any of the other exercises commonly used by bodybuilders trying to grow muscle tissue. They were just given large doses of the drug, and they grew like weeds.

    In comparison, human tolerance is very low, which allows only a small part of the doses administered to animals. Similarly, our anabolic response is relatively weak, and even when using high doses in the presence of beta blockers, there is virtually no increase in muscle mass (beta blockers can be used to help us tolerate high doses of clenbuterol, preventing a fatal acceleration of the heart rate). This difference in physiological response shows us very clearly that animal studies are often an unreliable indicator of human response. Of course, this doesn't mean that we should automatically discount the results, but we can't draw any conclusions from them.

    Equally important are the variables of relative dose and duration of use. The rats in the study (there were actually two studies) were given doses ranging from 5-80 mg/kg body weight per day with Wistar rats (the type of rats used in the study) usually weighing 1 pound or less, the following figures will be based on the rat's weight of ½ kg (just over 1 pound). Using this figure, the rats were given a dose of GW in the range of 2.5 to 40 mg per day. Applying the same dosage guidelines for humans, the equivalent dose for a 100 kg male would be 500-8000 mg per day. Most bodybuilders only use 5-20 mg/day, which means the rat dose was 25-160 times higher than what is normally used in humans.

    In addition, this study lasted 104 weeks; exactly 2 years. With Wistar rats having a life span of 2-3 years, these rats were treated for 66-100% of their life. If we put this in human terms (a typical bottle of GW-501516 contains 30 servings of 10 mg each), it would be like giving a newborn child 1.66-27 bottles of GW-501516 a day and continuing the treatment for the entire adult life or most of her life. With an average bodybuilding dose of 1/30 bottle a day for 30-60 days, only an ***** would equate the two. The factor of interspecific differences in physiological responses and any belief in extrapolation becomes incredibly difficult to maintain.

    Given the seriousness of the allegations (that GW-501516 causes cancer), even though it has little basis, we should still take it seriously. Fortunately, we are not left in the dark about the actual use of this drug, as 1,000 bodybuilders and other athletes have now been using it for more than half a century without experiencing any medical problems, let alone cancer. In addition, independent studies are conducted that do not show signs of cancer, even if the dosages used in the above-mentioned study are exceeded.

    When looking at the evidence as a whole, it seems that the initial fear of cancer was nothing more than fear. Let's not forget about all the other chemicals/medications that have been shown to cause cancer in research animals under similar circumstances, but were subsequently approved by the FDA and have now been used by the General public for decades. Artificial sweeteners, anyone? While I hate to pull the honesty card here, let's also not forget that Big Pharma isn't known as the most moral/honest organization in town. Selfishness is the middle name of Big Pharma, but I digress. At this point, while it's not certain that GW-501516 is safe (the same can be said for many other commonly used bodybuilding drugs), it seems that the risk is minimal, especially when following the usual rules of Cycling.

    Safety issues aside, what makes this such a great bodybuilding drug? While it doesn't produce overly dramatic results in any one area (with the possible exception of its positive effects on metabolic health), the totality of its effects can't help but be impressive. One of its most desirable benefits is its ability to stimulate fat loss. While I'm not going to go into the science of “how” this stuff works (there are already many articles on this topic), I want to touch on what makes GW-501516 different from its counterparts.

    Unlike most modern weight loss medications, GW does not stimulate the nervous system. Personally, I find this a relief, as there are many cases where I don't feel like fighting shivers, nervousness, anxiety, or post-drug use, all of which are common cases with medications like clenbuterol, ephedrine, caffeine, and all other stimulants. Like growth hormone, the effects of GW fat loss are not rapid, but they are consistent and constant, allowing us to accelerate fat loss over time without any of the typical side effects associated with nervous system stimulation. This alone makes it worth considering.

    It is also one of the few non-stimulant medications that causes fat loss through an increased rate of oxidation (using fat to burn fat energy). There are two main steps involved in fat loss: oxidation and lipolysis. Lipolysis is a term used to describe the release of fatty acids from a fat cell into the bloodstream, making them more likely to be used by the body for energy. Oxidation describes the use/burning of fat for energy. Both of these steps must occur in order for fat loss to take place. If fat is not first released from the fat cell, it cannot be used for energy. Similarly, if the newly released fat is not used for energy, it will simply be re-deposited in the fat cell.

    If one of these processes starts to exceed the other, the slower process is called the speed limiting factor. In other words, the rate of fat loss is limited to the weakest link. When it comes to fat loss, oxidation is usually a speed limiting factor. This makes GW-501516 an excellent growth hormone stacker, as its ability to increase oxidation combines well with the lipolytic effect of GH, increasing the rate of fat loss beyond what can be achieved with just one of them.

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    Huh, that was an interesting and very important info! Thanks!

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