I have tried, and now we fly. Your kids are both under 2, so they fly free. If that drive is going to take 3-4 days, that means you are paying for food and lodging for days - would be cheaper and so much easier to just fly. If extenuating circumstances are forcing you to drive, I highly suggest a dvd player for your vehicle (they can strap on to the back of the front seats and are only a few hundred) and Baby Einstein dvds.